Highlights:

  • Scientists have developed technology for patients waiting for liver transplantation worldwide
  • Now the liver will be made in the lab from the cells of the patients, the human body will not be able to reject
  • Brazilian scientists manufacture rat liver in lab, soon human organs will also be made

Sao Paulo
Scientists have found unique treatment for patients struggling with liver disease. It is often seen that patients have to face a lot of problems regarding liver transplant. Initially, the patients do not get liver easily, if found, they have to face long waiting list for transplant. Now scientists at the Human Genome and Stem Cell Research Center of the Sao Paulo Institute of Biosciences, Brazil, have developed the technique to regenerate and make liver in the lab.

First experiment on mice
Medical Express.com report states that scientists have carried out a proof-of-concept study with rat liver. In the next phase of this research, scientists are going to produce liver of humans for transplantation. The article published in Material Science states that the next plan is to mass produce human livers in the lab. This will reduce the suffering of patients looking for a donor and can also prevent the rejection of the transplanted organ.

Liver production is based on this technology
Luiz Carlos de Caires Jr., who wrote the article, stated that liver production is based on desicularization and resellularization technology. In recent times a lot of work has been done on tissue bioengineering techniques. He told that in this process we in the lab dissolve in a variety of detergents and enzymes to separate cells from the liver tissue of humans. This separates the extrasellular matrix and only the basic structure and the outer shape remain. After which the extracellular matrix is ​​placed with cells taken from the patient. Due to this, the patient’s body is not able to reject this liver after transplantation.

Therefore, the patient’s body will not be able to reject
Myna Zetz, the lead investigator of HUG-CELL, said that such a technique allows for easily reconstructed ‘reconditioned liver’. After such transplantation, the rejection rate of the organ is also low, because it is made from the patient’s cells. He also claimed that this technology can also repair organs considered non-transplantable.

This technique will be a boon for patients
Scientists said that many a times there is a situation that the organs of dead people cannot be transplanted in a traffic accident. But, with such technology, those organs can be corrected for transplantation. This technology is considered a boon for medical science because there are millions of people all over the world who are waiting for transplantation of different organs.

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